Hydrazine → HCID 9844212, compound

Participants

Reaction Steps

To a mixture of N-(2-{[3-(3-nitro-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide and hydrazine in ethanol at 5° C. was added Raney nickel (400 mg). After 0.5 hour another portion of Raney nickel (300 mg) was added and the reaction was heated to reflux for 1 hour. The catalyst was filtered and the solvent removed to afford N-(2-{[3-(3-amino-phenoxy)-propylamino]-methyl}-chroman-7-yl)-methanesulfonamide in 69.9% yield. The (2:1)oxalate, hemihydrate was prepared from tetrahydrofuran and triturated in methanol, mp 183°-185° C.

Provenance & Evidence