HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1376570Generated: October 31, 2026
Toluene → 2-(3-Methoxyphenoxy)-1-(4-methoxyphenyl)ethanone
https://huagongshe.com/reaction/1376570
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Bromomethyl 4-methoxyphenyl ketone | HCID 4965 | — |
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(3-Methoxyphenoxy)-1-(4-methoxyphenyl)ethanone | HCID 22743054 | — |
Reaction Steps
In a one liter round-bottom flask, fitted with a condenser and nitrogen inlet, were added 3-methoxyphenol (12.4 g, 0.1 mole), 4-methoxyphenacyl bromide (22.9 g, 0.1 mole), potassium carbonate (17.3 g, 0.125 mole) in 100 ml of 2-butanone. This mixture was heated to 80° C. and was maintained at this temperature for about four hours. The progress of the reaction was monitored by thin layer chromatography (silica gel, 9:1 toluene:ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05663192 |
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| Source dataset | uspto-grants-1997_09 |
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| ORD ID | ord-7f2d47938fab40a59944dd2415760272 |
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| Source note | uspto-grants-1997_09 |
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