Trifluoroacetic acid → HCID 22916669, compound

Participants

Reaction Steps

To 2.05 g of the above-obtained 2-[(N-tert-butoxycarbonylglycyl)amino]methylthiazole was added 10 ml of trifluoroacetic acid, and the mixture was stirred at room temperature for 30 minutes. The reaction solution was concentrated under reduced pressure. To the residue were added 10.74 g of ethyl trifluoroacetate and 3.83 g of triethylamine, and the mixture was stirred at room temperature for 30 minutes. The mixture was then concentrated under reduced pressure; and purified by flash column chromatography using silica gel, eluting first with ethyl acetate and then with a 20:1 mixture of ethyl acetate and methanol to give 1.98 g (yield 98%) of 2-[(N-trifluoroacetylglycyl)amino]methylthiazole as colorless crystals.

Provenance & Evidence