HCID 22916669, compound → HCID 22916686, compound

Participants

Reaction Conditions

Reaction Steps

To 1.98 g of the above-obtained 2-[(N-trifluoroacetylglycyl)amino]methylthiazole was added 20 ml of phosphorus oxychloride, and the mixture was heated and stirred at 100° C. for 4.5 hours. The reaction solution was cooled to room temperature, and concentrated to dryness under reduced pressure. The residue was dissolved in 30 ml of methylene chloride. To this solution was added 50 ml of water with ice- cooling. The pH of the mixture was adjusted to 8 by adding potassium carbonate little by little with ice-cooling, and the mixture was stirred for one hour. The crystals precipitated were collected by filtration, washed with cold water and a small amount of cold methylene chloride, and dried under reduced pressure to give 1.12 g (yield 60%) of 5-(trifluoro- acetylamino)methylimidazo[5,1-b]thiazole as light yellow crystals.

Provenance & Evidence