Hydrazine → HCID 23449290, compound

Participants

Reaction Steps

To a suspension of 0.379 g (1.34 mmole) of 7-(phthalimido)methylimidazo[5,1-b]thiazole in 15 ml of ehtanol was added 0.063 ml (2.0mmle) of anhydrous hydrazine, and the mixture was heated under reflux for 1 hour. The reaction mixture was ice-cooled, and the resulting crystalline products were removed by filtration. After the filtrate was concentrated under reduced pressure, a small amount of dichloromethane was added, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give crude 7-aminomethylimidazo[5,1-b]thiazole.

Provenance & Evidence