Benzyloxycarbonylglycine → HCID 73942757, compound

HRID 1376688Notes

Reaction equation

HRID 1376688 reaction equation
[NH:1]([C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7])[CH2:2][C:3]([OH:5])=O.[NH2:16][C@H:17]([C:26]([O:28][CH3:29])=[O:27])[CH2:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22]>CCCCCC>[NH:1]([C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7])[CH2:2][C:3]([NH:16][C@H:17]([C:26]([O:28][CH3:29])=[O:27])[CH2:18][C:19](=[O:25])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:5]

Participants

4

Reactant 2

HCID 14349BenzyloxycarbonylglycineHCID 7016379HCID 7016379, compound

Product 1

HCID 73942757HCID 73942757, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Analogously to Example 1 B)a), by coupling Z-Gly-OH and H-Asp(OtBu)-OMe there is obtained Z-Gly-Asp(OtBu)-OMe, m.p. 92°-95° C.(hexane), yield: 89% of theory.

Sources & evidence

ORD record
ord-2e0ca7ed0a7c4d248f105d9049077ffb
Source dataset
uspto-grants-1997_09
Patent number
US05663297

Reaction notes

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