HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-2-thiopseudourea sulfate → 1-Amidino-4-piperidinepropionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-2-thiopseudourea sulfate | HCID 75270 | — |
| Reactant | 3-(Piperidin-4-yl)propanoic acid | HCID 1520806 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 1-Amidino-4-piperidinepropionic acid | HCID 15583511 | 102.5% |
Reaction Steps
500 mg of 4-piperidinepropionic acid are added at 2° C. to a solution of 553 mg of S-methyl-isothiourea sulphate in 3.2 ml of 2N sodium hydroxide solution. After leaving to stand at room temperature overnight the separated crystals are filtered off, washed with water, acetone and ether and dried. There are obtained 600 mg of 1-amidino-4-piperidinepropionic acid, m.p. above 275° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05663297 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-d487a31094b04c2992cce8bd5ec35ad6 |
| Source note | uspto-grants-1997_09 |