HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amidino-4-piperidinepropionic acid → Diisopropyl Ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amidino-4-piperidinepropionic acid | HCID 15583511 | — |
| Reactant | H-Gly-Asp(OtBu)-Phe-OtBu | HCID 15674432 | — |
| Reactant | Pyridinium hydrochloride | HCID 21584435 | — |
| Product | Diisopropyl Ether | HCID 7914 | — |
| Product | tert-butyl (2S)-2-amino-3-phenylpropanoate | HCID 6931633 | — |
Reaction Steps
Analogously to Example 1B)e), by coupling 1.6 g of 1-amidino-4-piperidinepropionic acid with 1.8 g of H-Gly-Asp(OtBu)-Phe-OtBu in the presence of 928 mg of pyridinium hydrochloride there are obtained 2.1 g of N-[N-[N-[3-(1-amidino-4-piperidinyl)propionyl]glycyl]-3-t-butoxycarbonyl)-L-alanyl]-3-phenyl-L-alanine t-butyl ester, m.p. 104°-106° C. (diisopropyl ether; decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05663297 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-3774f3a1752b406797ab741a31ce7336 |
| Source note | uspto-grants-1997_09 |