Hydrochloric Acid → HCID 22918393, compound

Participants

Reaction Steps

A steady stream of argon is passed through a suspension of 245 mg (0.5 mmol) of 4-anilino-5-(3,4,5-trimethoxy-anilino)phthalic acid dimethylester in 1.6 ml of methanol, and a solution of 94.4 mg (2.25 mmol, 4.5 eq) of lithium hydroxide monohydrate and 10 mg sodium ascorbate in 0.8 ml of water is added. The reaction mixture is heated to reflux for 17 hours and then cooled to RT. The resulting mixture is treated dropwise with 0.5 ml of 4N hydrochloric acid, the green suspension is filtered, and the crystals are washed with water to yield the title compound in the form of green crystals, m.p. 145°-6° C., FAB-MS: 439 [M+ +H].

Provenance & Evidence