1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde → HCID 54004801, compound

HRID 1376789Notes

Reaction equation

HRID 1376789 reaction equation
[CH:1]([C:3]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1)=O.[NH:12]1[C:20]2[C:15](=[CH:16][C:17]([S:21]([OH:24])(=[O:23])=[O:22])=[CH:18][CH:19]=2)[CH2:14][C:13]1=[O:25]>C(O)C>[NH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][N:7]=2)[C:3]([CH:1]=[C:14]2[C:15]3[C:20](=[CH:19][CH:18]=[C:17]([S:21]([OH:24])(=[O:22])=[O:23])[CH:16]=3)[NH:12][C:13]2=[O:25])=[CH:4]1

Participants

4

Reactant 2

HCID 53728121H-Pyrrolo[2,3-b]pyridine-3-carbaldehydeHCID 21915562HCID 21915562, compound

Product 1

HCID 54004801HCID 54004801, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-formyl-7-azaindoie (1.46 g, 0.010 mol) and 2-oxindole-5-sulfonic acid (2.55 g, 0.012 mol) in absolute ethanol (10 ml) was heated to reflux for 1 h. The reaction mixture was chilled with ice water, the precipitate filtered, the residue washed with ice-cooled ethanol and dried under vacuum. Almost pure titie compound was obtained in about 70% yield (2.389 g).

Workup

  1. temperatureto reflux for 1 h
  2. filtrationthe precipitate filtered
  3. washthe residue washed with ice-
  4. temperaturecooled ethanol
  5. customdried under vacuum
  6. customAlmost pure titie compound was obtained in about 70% yield (2.389 g)

Sources & evidence

ORD record
ord-2ae82c6dd3d3434090bae51caecd146d
Source dataset
uspto-grants-1997_09
Patent number
US05663346

Reaction notes

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