1-(2-Hydroxyethyl)piperazine → HCID 70115076, compound

Participants

Reaction Steps

A mixture of 5-(chloromethyl)-3-[(7-azaindol-3-yl) methylene]-2-oxindole (3.098 g, 10 mmol), 4-hydroxyethyl-piperazine (2.604 g, 20 mmol) in 1N NaOH (20 ml, 20 mmol) was refluxed for 48 h. The cooled reaction mixture was extracted with ether, and the ether extract was shaken with diluted hydrochloric acid. The aqueous acid layer was made alkaline with potassium carbonate and extracted with ether. Addition of hydrogen chloride to the dried ether extract precipitated a crude hydrochloride which was crystallized twice from a mixture of methanol and ether.

Provenance & Evidence