HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (-)-6-[(4-chlorophenyl)hydrazinomethyl]-1methyl-1H-benzotriazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (+)-6-[(4-chlorophenyl)hydrazinomethyl]-1-methyl-1H-benzotriazole monohydrochloride | HCID 18924324 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (-)-6-[(4-chlorophenyl)hydrazinomethyl]-1methyl-1H-benzotriazole | HCID 18924312 | — |
Reaction Steps
To a suspension of 8.1 g of intermediate 2-b in 60 ml of dichloromethane was added a solution of 1 g sodium hydroxide in 15 ml of water. The whole was stirred for 15 min., then the organic layer was separated and evaporated. The residue and 1.4 g of potassium hydroxide were refluxed in 50 ml ethanol for 3 hours, yielding (-)-6-[(4-chlorophenyl)hydrazinomethyl]-1methyl-1H-benzotriazole (interm. 2-c); enantiomeric excess: 20%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05663354 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-960d6792c16446209bd33f5202babe93 |
| Source note | uspto-grants-1997_09 |