HCID 54386289, compound → HCID 54219298, compound

HRID 1376828Notes

Reaction equation

HRID 1376828 reaction equation
P(I)(I)OP(I)I.[C:8]([NH:27][C:28]1[S:29][CH:30]=[C:31]([C:33](=[N:56][O:57][CH3:58])[C:34]([NH:36][CH:37]2[C:44](=[O:45])[N:43]3[CH:38]2[CH2:39][S:40][CH:41]([CH2:54][CH3:55])[C:42]3(O)[C:46]([O:48][C:49]([CH3:52])([CH3:51])[CH3:50])=[O:47])=[O:35])[N:32]=1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>N1C=CC=CC=1>[C:8]([NH:27][C:28]1[S:29][CH:30]=[C:31]([C:33](=[N:56][O:57][CH3:58])[C:34]([NH:36][CH:37]2[C:44](=[O:45])[N:43]3[CH:38]2[CH2:39][S:40][C:41]([CH2:54][CH3:55])=[C:42]3[C:46]([O:48][C:49]([CH3:52])([CH3:50])[CH3:51])=[O:47])=[O:35])[N:32]=1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 54386289HCID 54386289, compoundHCID 86751199HCID 86751199, compound

Product 1

HCID 54219298HCID 54219298, compoundYield 32.5%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Using the procedure of Example 1, 560 mg of diphosphorous tetraiodide, 4.5 ml of pyridine and 394 mg of the product of Step B were reacted to obtain 125 mg of 1,1-dimethylethyl 7-[2-(2-tritylaminothiazol-4-yl)-2-methoxyimino-acetamido]-8-oxo-3-ethyl-4-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylate.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-624e556ec2b642bf9be0ad743b46e01e
Source dataset
uspto-grants-1997_09
Patent number
US05663164

Reaction notes

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