反应详情

A mixture of one liter of methylene chloride, 500 ml of water and 100 g of p-nitrobenzyl glycinate tosylate was strongly stirred while 26 ml of 10N sodium hydroxide were added dropwise and stirring was continued for 5 minutes after the addition. The decanted aqueous phase was extracted with methylene chloride and the combined organic phases were washed with water, dried and concentrated to dryness under reduced pressure at less than 40° C. to obtain 52.3 g of p-nitrobenzyl glycinate melting at 45°-50° C.

1. additionwere added dropwise
2. additionafter the addition
3. extractionThe decanted aqueous phase was extracted with methylene chloride
4. washthe combined organic phases were washed with water
5. customdried
6. concentrationconcentrated to dryness under reduced pressure at less than 40° C.