Hydrochloric Acid → HCID 14489186, compound

Participants

Reaction Steps

1.45 g of (6RS) (7RS) (4-nitrophenyl)-methyl 7-[(1,1-dimethylethyl)-oxycarbonyl-amino]-3-methylthio-8-oxo-4-thia-1-azabicyclo[4,2,0]oct-2-en 2-carboxylate, 30 ml of tetrahydrofuran, 30 ml of methanol and 1.45 g of 10% palladized carbon were hydrogenated under a pressure of 2 atmospheres of hydrogen, while being vigorously stirred. After one hour, the pressure was taken up to ambient, and under an inert atmosphere, 4 ml of N hydrochloric acid were added. After separation, the solvent was expelled under reduced pressure at 35° C. and the residue was taken up in 100 ml of distilled water. The mixture was extracted with methylene chloride and the organic phase was dried, and evaporated to dryness under reduced pressure to obtain 1.3 g of (6RS) (7RS) 7-[(1,1-dimethylethyl)-oxycarbonyl-amino]-3-methylthio-8-oxo-4-thia-1-azabicyclo[4,2,0]oct-2-en-2-carboxylic acid.

Provenance & Evidence