Ethanolamine → HCID 22918635, compound

HRID 1376888Notes

Reaction equation

HRID 1376888 reaction equation
[CH2:1]([N:8]1[C:12](Br)=[C:11]([N+:14]([O-:16])=[O:15])[C:10]([Br:17])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[CH2:19]([CH2:21][NH2:22])[OH:20]>>[CH2:1]([N:8]1[C:12]([NH:22][CH2:21][CH2:19][OH:20])=[C:11]([N+:14]([O-:16])=[O:15])[C:10]([Br:17])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 700EthanolamineHCID 962WaterHCID 196972381-Benzyl-3,5-dibromo-4-nitro-1H-pyrazole

Product 1

HCID 22918635HCID 22918635, compound

Procedure

3.61 (10 mmoles) of 1-benzyl-3,5-dibromo-4-nitropyrazole are heated at 80° C. in 15 ml ethanolamine for 2 hours. After cooling, the reaction mixture is poured on 30 ml water and the separated precipitate is collected by filtration. After recrystallizing once from toluene, 2.5 g (74 percent of theory) of 1-benzyl-3-bromo-5-(2'-hydroxyethyl)amino-4-nitropyrazole are obtained in the form of pale yellow crystals with a melting point of 110° to 112° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe separated precipitate is collected by filtration
  3. customAfter recrystallizing once from toluene, 2.5 g (74 percent of theory) of 1-benzyl-3-bromo-5-(2'-hydroxyethyl)amino-4-nitropyrazole
  4. customare obtained in the form of pale yellow crystals with a melting point of 110° to 112° C.

Sources & evidence

ORD record
ord-f3d0a10462fe43528a121baef4c9152c
Source dataset
uspto-grants-1997_09
Patent number
US05663366

Reaction notes

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