Sulfuric Acid → 2-((4-Amino-1-methyl-1H-pyrazol-5-yl)amino)ethanol

HRID 1376890Notes

Reaction equation

HRID 1376890 reaction equation
Br[C:2]1[C:6]([N+:7]([O-])=O)=[C:5]([NH:10][CH2:11][CH2:12][OH:13])[N:4]([CH3:14])[N:3]=1.S(=O)(=O)(O)O>O>[NH2:7][C:6]1[CH:2]=[N:3][N:4]([CH3:14])[C:5]=1[NH:10][CH2:11][CH2:12][OH:13]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 229186243-Bromo-5-(2'-hydroxyethyl)amino-1-methyl-4-nitropyrazole

Product 1

HCID 101762352-((4-Amino-1-methyl-1H-pyrazol-5-yl)amino)ethanolYield 122.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 g (3.77 mmoles) of 3-bromo-5-(2'-hydroxyethyl)amino-1-methyl-4-nitropyrazole are hydrogenated in a solution of 380 mg (3.77 mmoles) sulfuric acid in 50 ml water for 2 hours according to method (2). 720 mg (75 percent of theory) of 4-amino-5-(2'-hydroxyethyl)amino-1-methylpyrazole hydrosulfate are obtained in the form of colorless crystals with a melting point of 94° to 97° C.

Sources & evidence

ORD record
ord-dd9ff91ed6314efea24e52902df4b423
Source dataset
uspto-grants-1997_09
Patent number
US05663366

Reaction notes

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