Sulfuric Acid → 4-Amino-1-(2'-hydroxyethyl)-5-(2'-hydroxyethyl)aminopyrazole

HRID 1376891Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1376891
Br[C:2]1[C:6]([N+:7]([O-])=O)=[C:5]([NH:10][CH2:11][CH2:12][OH:13])[N:4]([CH2:14][CH2:15][OH:16])[N:3]=1.S(=O)(=O)(O)O>>[NH2:7][C:6]1[CH:2]=[N:3][N:4]([CH2:14][CH2:15][OH:16])[C:5]=1[NH:10][CH2:11][CH2:12][OH:13]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 229186333-Bromo-1-(2'-hydroxyethyl)-5-(2'-hydroxyethyl)amino-4-nitropyrazole

Produkt 1

HCID 229186234-Amino-1-(2'-hydroxyethyl)-5-(2'-hydroxyethyl)aminopyrazoleAusbeute 125,3 %

Reaktionsbedingungen

Temperatur
-30 °C

Versuchsvorschrift

0.8 g (2.7 mmoles) of 3-bromo-1-(2'-hydroxyethyl)-5-(2'-hydroxyethyl)amino-4-nitropyrazole are hydrogenated over a period of 4 hours according to method (1). After filtering the catalyst, 0.27 g (2.7 mmoles) sulfuric acid (97-percent) is added. After cooling to -30° C., 630 mg (82 percent of theory) of 4-amino-1-(2'-hydroxyethyl)-5-(2'-hydroxyethyl)aminopyrazole hydrosulfate are obtained in the form of colorless crystals with a melting point of 140° to 142° C.

Aufarbeitung

  1. additionis added

Quellen und Nachweise

ORD-Eintrag
ord-1857f8137d184bca9189dcd612c2f9e1
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05663366

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