Ammonia → HCID 22918653, compound

Participants

Reaction Steps

A solution of methyl 2,2-dichloro-2-(4-nitrophenyl)acetate (1.36 parts) in dichloromethane (13.6 parts) was stirred with concentrated ammonia solution (10 parts) at 25° C. for 24 hours before diluting the reaction mixture with water (50 parts) and extracting with dichloromethane. The dichloromethane extracts were washed with water and evaporated to give 2,2-dichloro-2-(4-nitrophenyl)acetamide (0.86 parts, 63,4%) (1Hnmr in D6 dimethylsulphoxide 87.95 medium (2H), 88,23 broad (2H), δ8.35 medium (2H)).

Provenance & Evidence