反应详情

A solution of 3,4-diacetoxycinnamoyl chloride (5.61 g, 19.9 mmol) in dichloromethane (50 ml) was dropped into a solution of the N-(2-indanyl)-4-(methylamino)benzenesulfonamide (5.00 g, 16.6 mmol) prepared in Preparative Example 14 in pyridine (50 ml) at 0° C. The obtained mixture was stirred at room temperature for 2 hours, followed by the addition of water. The obtained mixture was extracted with ethyl acetate. The organic layer was washed with 1N aqueous hydrochloric acid and a saturated aqueous solution of common salt, dried over magnesium sulfate, and concentrated to give a solid residue. This residue was recrystallized from ethyl acetate/ether/isopropyl ether to give the title compound as a white crystal (8.90 g, 100%). m.p. (°C.): 152~153 (iso-Pr2O)

1. extractionThe obtained mixture was extracted with ethyl acetate
2. washThe organic layer was washed with 1N aqueous hydrochloric acid
3. dry with materiala saturated aqueous solution of common salt, dried over magnesium sulfate
4. concentrationconcentrated
5. customto give a solid residue
6. customThis residue was recrystallized from ethyl acetate/ether/isopropyl ether