Butanal → 2-Ethyl-3-hydroxyhexanal

HRID 1377113Notes

Reaction equation

HRID 1377113 reaction equation
[CH2:1]([CH:3]([CH2:6][OH:7])[CH2:4][OH:5])[CH3:2].[CH:8](=O)[CH2:9][CH2:10]C>C(O)CCC>[CH2:1]([CH:3]([CH:6]([OH:7])[CH2:8][CH2:9][CH3:10])[CH:4]=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 261ButanalHCID 1022932-Ethylpropane-1,3-diol

Product 1

HCID 103242-Ethyl-3-hydroxyhexanalYield 52.6%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

JP patent publication 1 299 240 discloses a process for the preparation of 2-ethyl-1,3-propane diol from n-butyraldehyde by aldol condensation by using alkali metal alkoxides as the catalyst. The reaction was performed in the presence of sodium methoxy in a butanol solution at 40° C. 2-Ethyl-3-hydroxyhexanal formed with a yield of 52.6%, and it was hydrogenated with Raney nickel at a temperature of 100° C. and a pressure of 50 atm.

Workup

  1. customby aldol condensation

Sources & evidence

ORD record
ord-aacc315398bf4e9c81b9fae28ebc159c
Source dataset
uspto-grants-1997_09
Patent number
US05663452

Reaction notes

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