Lithium Hydroxide → 5(S)-(Boc-Amino)-4(S)-hydroxy-6-phenyl-2(R)-[(2,4-difluorophenyl)methyl]hexanoic acid

Participants

Reaction Steps

In analogy with Example 1i), 3.1 g (7.18 mmol) 5(S)-[1(S)-(Boc-amino)-2-phenyl-ethyl]-3(R)-[(2,4-difluorophenyl)methyl]dihydrofuran-2-(3H)-one in 77 ml of dimethoxyethane and 19 ml of water are hydrolysed with 28.7 ml of a 1M lithium hydroxide solution (19 h at RT) to give the title compound: tRet (II)=14.7 min.

Provenance & Evidence