反应详情

4-Carboxy-1-ethoxycarbonylpiperidine is prepared from piperidine-4-carboxylic acid (Aldrich, Steinheim, FRG), for example by reacting piperidine-4-carboxylic acid with ethyl chloroformate in aqueous sodium hydroxide solution for 2 h at from 0° to 5° C. The title compound is extracted from the aqueous phase by shaking with toluene. The toluene phase containing the dissolved title compound is dried over Na2SO4 and directly subjected to further use.

1. customfor 2 h
2. customat from 0° to 5° C
3. extractionThe title compound is extracted from the aqueous phase
4. additionThe toluene phase containing the
5. dissolutiondissolved title compound
6. dry with materialis dried over Na2SO4