Hydroxylamine → 2H-1,2-Benzoxazin-3(4H)-one

Participants

Reaction Conditions

Reaction Steps

The amino-alcohol was dissolved in THF (15 ml) and cooled to -10° C. under N2. To the mixture was added triethylamine (5.4 ml) and phosgene in toluene (4.6 ml). The addition of phosgene caused an exotherm which was maintained below 20° C. by the rate of addition. The progress of the reaction was monitored by HPLC and was typically complete in 15 minutes.

Provenance & Evidence