Sodium Hydroxide → HCID 22913223, compound

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Reaction Steps

A mixture of lithium aluminum hydride (0.1 g) with THF (10 ml) was stirred under ice cooling, followed by gradually dropwise adding a mixed solution of (+)-ethyl 2-butoxy-3,3,3-trifluoropropionate (0.8 g) obtained in Example 7 with THF (5 ml), followed by raising the temperature up to room temperature, stirring for one hour, again cooling with ice, dropwise adding 2N NaOH aqueous solution, filtering off deposited substance, extracting with ether (50 ml), washing with saturated NaCl aqueous solution, drying over anhydrous magnesium sulfate and removing the solvent. Yield: 0.5 g. [α] -11.7 (cl. 0, CHCl3)

Provenance & Evidence