ethyl 2-(2-nitro-1H-imidazol-1-yl)acetate → 2-(2-Nitroimidazol-1-yl)acetic acid

HRID 1377388Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1377388
[N+:1]([C:4]1[N:5]([CH2:9][C:10]([O:12]CC)=[O:11])[CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2]>[OH-].[Na+]>[N+:1]([C:4]1[N:5]([CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2]

Komponenten

3

Edukt 1

HCID 327541ethyl 2-(2-nitro-1H-imidazol-1-yl)acetate

Produkt 1

HCID 3275442-(2-Nitroimidazol-1-yl)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

Ethyl 2-(2-nitro-1H-imidazol-1-yl)acetate was suspended in 1N NaOH (100 mL) and stirred at room temperature until it turned into a clear solution. The solution was cooled in an ice-bath and neutralized to pH~2 to give a white precipitate. The solid was filtered and washed with water (3×25 mL). Yield: 11.5 g (97%). MS: 189 (M+NH4)+, 172 (M+H)+, 170 (M-H)-. 1H NMR (DMSO-d6) δ5.22 [s, 2H, C H2 -(2-nitroimidazole)], 7.22 and 7.65 (s, 2H, 2-nitroimidazolyl- H).

Aufarbeitung

  1. temperatureThe solution was cooled in an ice-bath
  2. customto give a white precipitate
  3. filtrationThe solid was filtered
  4. washwashed with water (3×25 mL)

Quellen und Nachweise

ORD-Eintrag
ord-7941eb7e2a7844a0842229ecf5770fb5
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05665329

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