Triethyl Phosphate → HCID 178447774, compound

Participants

Reaction Steps

22.7 g (0.1 mol) of 4-(3-bromopropyl)-1-ethylbenzene was dropped in a mixture of 2.5 g (0.11 mols) of magnesium and 300 ml of THF to obtain a Grignard reagent. The resultant solution was further dropped in a solution, in 500 ml of THF, of 0.5 g of triethyl phosphate, 0.1 g of copper (I) iodide and 34.5 g (0.1 mol) of trans-4-(trans-4-bromomethylcyclohexyl)-1-pentyl-1-silacyclohexane. The resultant product was subjected to ordinary aftertreatments to obtain trans-4-(trans-4-(4-(4-ethylphenyl)butyl)cyclohexyl)-1-pentyl-1-silacyclohexane. After ordinary aftertreatments, the product was purified through chromatography to obtain 32.6 g (yield: 79%) of the trans isomer product.

Provenance & Evidence