Triethyl Phosphate → HCID 178447966, compound

Participants

Reaction Steps

21.9 g (0.1 mol) of trans-4-bromomethyl-1-n-propyl-1-silacyclohexane was dropped in a mixture of 2.5 g (0.11 mols) of magnesium and 300 ml of THF to obtain a Grignard reagent. The resultant solution was then dropped in a solution, in 500 ml of THF, of 0.5 g of triethyl phosphate, 0.1 g of copper (I) iodide and 40.1 g (0.1 mol) of 4-(trans-4-(3-bromopropyl)-4-silacyclohexyl) -2,6-difluoro-1-trifluormethylbenzene. The resultant product was subjected to ordinary aftertreatments to obtain trans-4-(4-(trans-4-(3,5-difluoro-4-trifluoromethylphenyl)-1-silacyclohexyl)butyl)-1 -n-propylcyclohexane, followed by isolation through chromatography to obtain 37.2 g (yield: 81%) of the intended trans isomer product.

Provenance & Evidence