Triethyl Phosphate → HCID 131720184, compound

Participants

Reaction Steps

33.5 g (0.1 mol) of 4-(4-bromocyclohexyl)-1-(1,2,2-trifluorovinyloxy)benzene was dropped in a mixture of 2.5 g (0.11 mols) of magnesium and 300 ml of THF to obtain a Grignard reagent. The resultant solution was then dropped in a solution, in 500 ml of THF, of 0.5 g of triethyl phosphate, 0.1 g of copper (I) iodide and 29.1 g (0.1 mol) of trans-4-(4-bromobutyl)-1-n-butyl-1-silacyclohexane. The resultant product consisted of a mixture of tram and cis isomers with respect to the cyclohexane ring. The product was subjected to ordinary aftertreatments to obtain trans-4-(4-(trans-4-(1,2,2-trifluorovinyloxy)phenyl)cyclohexyl)butyl)-1-n-butyl-1-silacyclohexane, followed by isolation through chromatography to obtain 17.1 g (yield: 37%) of the intended trans isomer product.

Provenance & Evidence