Thionyl Chloride → Acridine-1-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

Acridine carboxylic acid hydrate (4.6 g, made by Aldrich Chemical Company) was dissolved in 200 ml of dioxane, and 2.4 g of thionyl chloride (made by Kanto Kagaku K.K.) was added thereto dropwise. The reaction was carried out at 60° C. for 1 hour. To this was further added 1.15 g of arylamine and heated at 60° C. for 2 hours. The solution was concentrated under reduced pressure to 50 ml, crystallized by ice cooling, and separated by filtration to obtain 2.2 g of arylamineamide of acridine carboxylic acid.

Provenance & Evidence