2-Acetyl-6-fluorobenzoic acid → HCID 178466551, compound

HRID 1377427Notes

Reaction equation

HRID 1377427 reaction equation
[F:1][C:2]1[C:7]([C:8]([OH:10])=O)=[C:6]([C:11](=[O:13])[CH3:12])[CH:5]=[CH:4][CH:3]=1.[F:14][C:15]1[CH:16]=[C:17]([NH:22][C:23](=[O:26])[NH:24][NH2:25])[CH:18]=[C:19]([F:21])[CH:20]=1>CO>[F:14][C:15]1[CH:16]=[C:17]([NH:22][C:23](=[O:26])[NH:24][N:25]=[C:8]([OH:10])[C:7]2[C:2]([F:1])=[CH:3][CH:4]=[CH:5][C:6]=2[C:11](=[O:13])[CH3:12])[CH:18]=[C:19]([F:21])[CH:20]=1

Participants

4

Reactant 2

HCID 152786862-Acetyl-6-fluorobenzoic acidHCID 152786873-Amino-1-(3,5-difluorophenyl)urea

Product 1

HCID 178466551HCID 178466551, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3 g of 6-fluoro-2-acetyl benzoic acid and 3 g of 4-(3,5-difluorophenyl)semicarbazide are mixed in 20 ml of methanol and heated until clear. The solution is then stirred at R.T. for 24 hr. A white solid forms which is filtered and dried in vacuum at 60° to yield the title product m.p. 227° (decomp.). The corresponding sodium salt is made by reaction of the free acid with 25% sodium methoxylate/methanol.

Workup

  1. temperatureheated until clear
  2. filtrationA white solid forms which is filtered
  3. customdried in vacuum at 60°

Sources & evidence

ORD record
ord-5922514a87e942cb8d46cea808455b02
Source dataset
uspto-grants-1997_09
Patent number
US05665673

Reaction notes

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