HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 8-(2-tert-Butoxycarbonylamino-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Tert-butoxycarbonylamino-6-methylbenzylchloride | HCID 14368482 | — |
| Reactant | 2,3-Dimethylimidazo[1,2-a]pyridin-8-amine | HCID 21873980 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-(2-tert-Butoxycarbonylamino-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine | HCID 23287297 | — |
Reaction Steps
The title compound is prepared according to the procedure described for example 1 starting from 8-amino-2,3-dimethylimidazo[1,2-a]pyridine (4.8 g), 2-tert-butoxycarbonylamino-6-methylbenzylchloride (9.2 g), sodium iodide (5.5 g) and sodium carbonate (8.0 g) in acetone (250 ml). Purification by chromatography on silica gel (toluene/dioxane 20:1 as eluent) and crystallization from diisopropyl ether yield 7.1 g (62%) of m.p. 149°-152° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665730 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-6b041329237442c88929f711d8377873 |
| Source note | uspto-grants-1997_09 |