Water → HCID 15839869, compound

Participants

Reaction Steps

1.2 g (3.7 mmol) of methyl 2-methyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanoate are dissolved in 80 ml of methanol in a 250 ml round-bottomed flask, 0.25 g (6.25 mmol) of sodium hydroxide pellets and 1 ml of water are added and then the mixture is stirred at room temperature for 1 h and at reflux for 2 h. The mixture is cooled, the solvent is evaporated under reduced pressure, the residue is taken up in 50 ml of water and 50 ml of diethyl ether, and 36% hydrochloric acid is added dropwise. The insoluble material is collected by filtering, is washed with water and is dried. 0.91 g (2.96 mmol) of white solid is obtained. Melting point: 138°-140° C.

Provenance & Evidence