HCID 22914863, compound → HCID 22914883, compound

Participants

Reaction Steps

50 mg (0.076 mmole) of the compound obtained in step 1 of Example 12 was dissolved in 3 ml of methylene chloride and to the resulting solution was added 64.5 mg (0.152 mmole) of Des-Martin reagent. The resultant was stirred for 2 hours at room temperature and 10 ml of methylene chloride was added additionally thereto. The reaction mixture was washed with 5 ml of aqueous sodium bicarbonate solution, dried over anhydrous Na2SO4, concentrated under reduced pressure and purified with silica gel column chromatography to obtain 43.7 mg of the title compound (yield 87.8%).

Provenance & Evidence