HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-Glycyl-3(R)-methyl-beta-alanine benzyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-t-Butoxycarbonylglycyl-3(R)-methyl-beta-alanine benzyl ester | HCID 86751222 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-Glycyl-3(R)-methyl-beta-alanine benzyl ester hydrochloride | HCID 86751220 | — |
Reaction Steps
N-t-Butoxycarbonylglycyl-3(R)-methyl-β-alanine benzyl ester 2-4 (3.32 g) in EtOAc (100 mL) cooled to -60° C. was treated with HCl gas until saturated. The mixture was stirred for 30 minutes then the solvent was removed and the residue triturated with ether to give 2-5 as a solid. ##STR59##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665723 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-2cf44ff24aca4f94a7b6f91491821ff0 |
| Source note | uspto-grants-1997_09 |