HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → HCID 22876645, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Bis(2-chloroethyl)amine hydrochloride | HCID 522769 | — |
| Reactant | Ethanol ammonium hydroxide water | HCID 86596525 | — |
| Reactant | HCID 86751223 | HCID 86751223 | — |
| Product | HCID 22876645 | HCID 22876645 | — |
Reaction Steps
N-{[6-Amino-2,3-dihydro-1(1H)-isoindolone-2-yl]acetyl}-(R)-methyl-β-alanine (2-7) (203 mg, 0.7 mmol) and bis(2-chloroethyl) amine hydrochloride (137 mg, 0.77 mmol) in n-butanol (10 mL) were heated at 110° C. for 3 days. The solvent was removed and the residue chromatographed OEtOH/H2O/NH4OH 10:0.5:0.5) to give 2-8. Rf (silica; EtOH/H2O/NH4OH 10:0.5:0.5)=0.61. ##STR62##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665723 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-1e00e3d8d5bf4a09af1dfd63d99ebf66 |
| Source note | uspto-grants-1997_09 |