HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 22915162, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | p-tolylmethyl N-(pyrazine-2-carbonylamino)carbamate | HCID 478568 | — |
| Reactant | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 54262211 | HCID 54262211 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22915162 | HCID 22915162 | — |
Reaction Steps
(Trifluoromethyl)trimethylsilane (494 μl) was added to a stirred solution of bis(4-methyl-5-thiazolyl) ketone (500 mg) in anhydrous tetrahydrofuran (20 ml) at room temperature. After 1 hour, tetrabutylammonium fluoride (300 mg) was added. The mixture was stirred for 2 hours and then 3M hydrochloric acid was added. After 10 minutes the reaction mixture was adjusted to pH10 by the addition of 5M potassium hydroxide. The organic phase was separated and then worked-up in the usual manner to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665747 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-5c8d1113aca1406389cd37a7b96b90bd |
| Source note | uspto-grants-1997_09 |