反应详情

To a mixture of 5.0 g (16.2 mmole) of (1-methyl-4-piperidinyl) [3-(2-phenylethyl)-2-pyridinyl]methanone (which can be prepared in the same manner as described in Preparative Example 1, Steps A-D) in 70 mL of methanol was added portionwise 0.8 g (21.1 mmole) of sodium borohydride. The next day the solution was concentrated in vacuo to give a slurry which was dissolved in water and extracted with CHCl3. The combined organic portions were dried over MgSO4, filtered, and concentrated in vacuo to provide a liquid which was distilled (bp 190°-195° C. 1 mm Hg) to give 4.4 gms of the title compound as a viscous oil.

1. customcan be prepared in the same manner
2. concentrationThe next day the solution was concentrated in vacuo
3. customto give a slurry which
4. extractionextracted with CHCl3
5. dry with materialThe combined organic portions were dried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customto provide a liquid which
9. distillationwas distilled (bp 190°-195° C. 1 mm Hg)