Methyl iodide → HCID 22914791, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 500 mg (1.42 mmole) of 8-chloro-11-(1-acetyl-4-piperidylidene)-6,11-dihydro-5 H-benzo[5,6]cyclohepta[1,2-b]pyridine and 175 μl (2.81 mmole) of methyl iodide in 30 mL of toluene was heated at 100° C. for about 19 hours. The reaction mixture was cooled to room temperature and the solvent decanted off. The remaining residue was recrystallized twice from CH2Cl2 isopropyl etherexanes to give 432 mg of the title compound as tan crystals. (m.p. 245°-247° C.).

Provenance & Evidence