HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylparaben → HCID 53718815, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylparaben | HCID 8434 | — |
| Reactant | tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate | HCID 2763851 | — |
| Reactant | HCID 178473588 | HCID 178473588 | — |
| Product | HCID 53718815 | HCID 53718815 | — |
Reaction Steps
N-t-Butyloxycarbonyl-3-piperidinylmethanol was etherified with ethyl 4-hydroxybenzoate using the DEAD/triphenylphosphine procedure given in Step 1 of Example 25. The crude product was purified by pressurized silica gel column chromatography using a gradient elution of 10-25% EtOAc-hexanes. 4-(N-t-Butyloxycarbonyl-3-piperidinylmethoxy)benzoic acid ethyl ester was obtained as an oil (58% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665719 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-c372e212bf75426b9c70a48b84b4864a |
| Source note | uspto-grants-1997_09 |