Hydrochloric Acid → HCID 22914708, compound

Participants

Reaction Steps

4-(t-Butyloxycarbonyl)-1 -methoxycarbonyl-2-methoxybenzene (770 mg, 2.9 mmol) from Step 3 was dissolved in 1:1 THF:H2O (10 mL) and to the solution was added 1N NaOH (4 mL, 4 mmol). After being stirred at ambient temperature for 24 h, the solution was acidified to pH 2 with 1N HCl and the solvents were removed under reduced pressure. The residue was dissolved in CHCl3 and washed with water. The CHCl3 layer was dried (MgSO4), filtered, and evaporated under reduced pressure to give 4-(t-butyloxycarbonyl)-2-methoxybenzene 1-carboxylic acid as a white solid (86% yield).

Provenance & Evidence