2-(2-aminophenyl)propan-2-ol → HCID 22914661, compound

HRID 1377691Notes

Reaction equation

HRID 1377691 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH3:11])([CH3:10])[OH:9].[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][C:22](=O)[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13]>>[CH3:10][C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][CH:22]1[CH2:23][CH2:24][N:19]([C:17]([O:16][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:18])[CH2:20][CH2:21]1)([OH:9])[CH3:11]

Participants

3

Reactant 2

HCID 2535272-(2-aminophenyl)propan-2-olHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22914661HCID 22914661, compound

Procedure

2-Aminophenyldimethyl carbinol from Step 1 was reductively alkylated with 1-t-butyloxycarbonyl-4-piperidinone (2.6 g, 13.2 mmol) by the procedure given in Step 2 of Example 1 to give 4-(2-(1-methyl-1-hydroxyethyl)phenyl)amino-1-t-butyloxycarbonylpiperidine as an oil.

Sources & evidence

ORD record
ord-62402918c466489ab22066f39c28b594
Source dataset
uspto-grants-1997_09
Patent number
US05665719

Reaction notes

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