Diethylamine → HCID 22914666, compound

Participants

Reaction Steps

To a solution of 1-(1-(4-(N-vinylsulfonyl-4-piperidinyloxy)-2-methoxybenzoyl)piperidin-4-yl)-3,4-dihydro-2(1H)-quinolinone (80 mg, 0.14 mmol) from Example 192 in 5 mL of dry MeOH was added diethylamine (0.14 mL, 1.4 mmol) and the reaction stirred at ambient temperature for 16 hours. The solvent was removed under reduced pressure and the residue was purified by pressurized silica gel column chromatography using 98:2 CH2Cl2 :MeOH as eluant. The product-containing fractions were combined and the solvent was removed under reduced pressure. The residue was dissolved in EtOAc and the solvent was removed under reduced pressure to give the title compound as an amorphous solid.

Provenance & Evidence