Chloromethyl ethyl ether → HCID 21459514, compound

Participants

Reaction Steps

To a solution of 560 mg of 5-nitropyrrole-2-carbonitrile (4 mmol) in 20 mL of dry THF, is added 515 mg of potassium tert-butoxide (4.6 mmol). After the addition of 0.45 mL of chloromethylethylether (4.8 mmol) to the mixture, the mixture is stirred for 4 hours, then diluted with ether (30 mL) and water (50 mL). The organic layer is separated, washed with water MgSO4 (20 mL) and dried over MgSO4. After evaporation of the solvent a red oil is obtained (600 mg, 75%) 1-(ethoxymethyl)-5-nitropyrrole-2-carbonitrile. Anal. Calcd: C, 49.23%; H, 4.65%; N, 21.53%. Found: C, 49.40%; H, 4.07%; N, 21.30%.

Provenance & Evidence