HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Bromo-5-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Methoxybenzoic Acid | HCID 11461 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-5-methoxybenzoic acid | HCID 89906 | 79% |
Reaction Steps
To a mixture of m-anisic acid (250 g, 1.67 mol) in acetic acid (1 L) was added bromine (85 mL) and then water (1L). The mixture was heated to reflux, cooled in an ice bath and the product which precipitated was collected by filtration and washed with water to afford 305.7 g (79%) of 2-bromo-5-methoxybenzoic acid, m.p. 154°-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05665760 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-19b33d4ddd0144388c8e67d75f96f764 |
| Source note | uspto-grants-1997_09 |