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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1377880Generated: October 25, 2026

Sodium Bicarbonate → (S)-Benzyl piperidine-2-carboxylate

https://huagongshe.com/reaction/1377880

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium BicarbonateHCID 516892—
ReactantBenzyl piperidine-2-carboxylateHCID 12436232—
SolventEthyl AcetateHCID 8857—
Product(S)-Benzyl piperidine-2-carboxylateHCID 12436231—

Reaction Steps

Benzyl pipecolate was routinely generated by treating an ethyl acetate suspension of this salt with saturated sodium bicarbonate until dissolution of the organic material. The aqueous layer was extracted twice with ethyl acetate and the combined organic extracts were dried with MgSO4 and evaporated to yield (S)-Benzyl pipecolate (15) as a pale yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05665774
Source datasetuspto-grants-1997_09
ORD IDord-d97a83adc86d4fec85c6e1e641d731c5
Source noteuspto-grants-1997_09