Ammonia → HCID 22915486, compound

Participants

Reaction Steps

The desired compound was prepared according to the method of Example 29, step 5, except substituting 2-tert-butyloxycarbonylmethyl-4-[4-(4-cyanophenyl)phenoxy]butanoic acid, prepared as in step 3, for 3-methyl-2-[4-(4-cyanophenyl)phenoxy]butanoic acid. 1H NMR (DMSO-d6) δ 1.38 (s, 9H), 1.76-1.98 (m, 2H), 2.36 (dd, 1H, J=6, 15 Hz), 2.45-2.58 (m, 1H), 2.58-2.70 (m, 1H), 3.90-4.50 (m, 2H), 7.03 (d, 2H, J=9 Hz), 7.72 (d, 2H, J=9 Hz), 7.82-7.91 (m, 4H), 10.58 (s, 1H). MS (DCI/NH3) 411 (M+H)+, 428 (M+NH4)+, 372, 354. Anal Calcd. for C23H26N2O5.1.25 H2O: C, 63.80; H, 6.63; N, 6.46. Found: C, 63.67; H, 6.17; N, 6.41.

Provenance & Evidence