Methanol → HCID 21466888, compound

Participants

Reaction Conditions

Reaction Steps

Into a 500-ml flask were placed 13.2 g of glycylglycine, 200 ml of methanol, 20 g of triethylamine, and 15 g of carbon disulfide. The contents were stirred at 30° C. for 1 hour. A solution of 12.3 g of ethyl chloroacetate in 50 ml of methanol was added thereto dropwise, and this mixture was stirred at room temperature for 30 minutes. The resulting solution assumed a yellowish orange color. After the solvent was distilled off under reduced pressure, 50 ml of ethanol was added to the residue, and a solution of 15 g of potassium acetate in 300 ml of ethanol was added thereto. The crystals precipitated were taken out by filtration and washed with ethanol to obtain 15.4 g of rhodanin-3-ylmethylcarbamoylacetic acid.

Provenance & Evidence