Water → HCID 53807155, compound

Participants

Reaction Steps

6.31 g (21 mmol) of (S)-7-fluoro-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxamide were suspended in 20 ml of dioxan and 3.6 ml of pyridine and treated dropwise at 5° to 10° with 3.3 ml of trifluoroacetic anhydride. The reaction mixture was stirred at room temperature overnight and poured into 150 ml of water. The suspension obtained was filtered and the crystals were dried. There were obtained 5.36 g (90%) of (S)-7-fluoro-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carbonitrile of m.p. 254°-256°.

Provenance & Evidence