Water → HCID 54435252, compound

Participants

Reaction Steps

7.5 g (22.3 mmol) of (S)-8-trifluoromethyl-12,12a-dihydro-9-oxo-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxamide were suspended in 40 ml of dioxan and 4 ml of pyridine and treated dropwise with 3.6 ml of trifluoroacetic anhydride at 7 to 10° within 10 min. The mixture was stirred at room temperature for 3/4 hour and poured into 300 ml of water. The suspension obtained was filtered and, after drying the residue, there were obtained 3.75 g (52%) of (S)-8-trifluoromethyl-12,12a-dihydro-9-oxo-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carbonitrile of m.p. 115°-119°.

Provenance & Evidence